Horses are athletes who regularly has periods of intense physical activity and often met with difficulties in maintaining high levels of performance. In skeletal muscle, in fact, occurs a phenomenon known as hypoxia (oxygen deficiency) caused by the fact that the muscle fibers use more oxygen than the blood flow is able to provide it through circulation. Several studies have shown that while at rest or moderate physical activity the skeletal muscle has an excellent ability to replenish ATP, when the intensity of the effort increases to very high levels, we see a drastic reduction in the levels of ATP and other adenine nucleotides (ADP and AMP).
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